The company has made significant clinical progress in it's ongoing Phase 1b/2 study has shown that AU-011 is well-tolerated, with a statistically significant reduction in tumour growth rate and preservation of visual acuity at long term follow up, even in high risk patients. AU-011 has received both Orphan Drug and Fast Track designations by the FDA. Existing radioactive treatments are associated with numerous comorbidities, most notably the severe loss of vision and the potential for enucleation (removal of the eye). Overall, choroidal melanoma is a highly metastatic disease associated with high morbidity and mortality with no drugs approved to date. This causes acute cellular necrosis and a secondary pro-immunogenic antitumor response, while leaving surrounding tissue fundamentally intact.Īura is developing a lead product candidate AU-011 (belzupacap sarotalocan) for the treatment of early stage primary choroidal melanoma and choroidal melanoma suspects (collectively referred to as early stage CM), a rare and life-threatening ocular cancer with an incidence of approximately 11,000 patients a year world-wide. The whole concept is very niche - and the game is not well made enough to provide players with any sort of enjoyment outside of the references to the anime.Aura is a clinical-stage biopharmaceutical company developing a new class of oncology therapies based on a novel tumor targeting technology for initial application in primary tumors such as ocular and bladder cancers with the potential to treat other cancers.Īura’s initial therapeutic candidates have a dual selectivity mechanism with targeted binding of AU-011 to cancer cells, followed by activation using focused infrared laser light over the tumor. Those that are not familiar with the anime - Extreme Stage will be a poor choice of racer. About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features Press Copyright Contact us Creators. Nothing here is working - an Initial D fan may say otherwise, though. What's further frustrating is the entire game seems to be a showcase for Japanese car brands - where the cars you select are only the latest models available to the nation. Nor any sequences that make you take any interest in what is going on around you. There are no mechanics that improve on your vehicle or driver's statistics. There is no real progression in the game. Initial D Extreme Stage was made to be played in short bursts. this initial stage is somewhat sweet, medicinal and balsamic, it is also powerful and can. The visuals are reminiscent of the old racing arcade games - environments are blocky with only real model detailing on the cars. AURA MUGLER by Mugler is a Woody Aromatic fragrance for women. The game features all the characters, cars and tracks (except for Akina Snow) from Version 3 of the arcade game, as well as additional content. There is absolutely no skill in the world that could help maintain the equilibrium of your vehicles. Initial D: Street Stage is a video game based on the manga and anime Initial D.It was released on Februfor the Sony PlayStation Portable.It is based on Version 3 of Initial D Arcade Stage. The controls are overly sensitive, resulting in frequent spins and crashes. Initial D Extreme Stage is one of the most clunky racers available on the market. The racing is a mix of rallying with drifting, awkward terrain and the need for durable cars and street racing where sleek aerodynamism is necessary: all of. There won't be any sugarcoating here - for a franchise in a genre that's not particularly difficult to develop - the publishers have to do better here. It's definitely the latter, where the game feels and plays like a port of the arcade version.
Or maybe that there really isn't much that differs between the previous incarnations of the Initial D game, and it is the same as its predecessor Initial D Arcade 4. Perhaps there are not enough enthusiasts of the franchise to justify mass distribution.
There may be a reason why Initial D Extreme Stage never saw a western release.